01 - Combine buttermilk and hot sauce in a large bowl. Add chicken pieces, turn to coat thoroughly, cover, and refrigerate for at least 2 hours or overnight for optimal flavor penetration.
02 - Preheat oven to 450°F. Whisk flour, baking powder, baking soda, and salt in a large bowl. Cut in cold butter until mixture resembles coarse crumbs. Pour in buttermilk and stir just until combined.
03 - Turn dough onto a floured surface, gently pat to 3/4-inch thickness. Fold dough over itself 2-3 times for flaky layers, then pat out again. Cut biscuits using a 2.5-inch round cutter and place on a parchment-lined baking sheet. Bake 12-15 minutes until golden brown. Brush tops with honey or melted butter if desired.
04 - Combine flour, paprika, garlic powder, onion powder, cayenne, salt, and black pepper in a large bowl. Remove chicken from marinade, allowing excess to drip off. Dredge each piece thoroughly in the seasoned flour mixture, pressing lightly to adhere.
05 - Heat 1.5 inches of vegetable oil in a deep skillet or Dutch oven to 350°F. Fry chicken in batches, turning occasionally, until golden brown and cooked through to an internal temperature of 165°F, about 12-15 minutes per batch. Drain on a wire rack or paper towels.
06 - Plate warm fried chicken alongside hot buttermilk biscuits. Serve immediately while both components are at their optimal temperature and texture.