01 - Whisk together buttermilk, hot sauce, salt, and pepper in a large bowl. Add chicken pieces and turn to coat thoroughly. Cover and refrigerate for at least 4 hours or overnight for optimal tenderness.
02 - Combine flour, paprika, garlic powder, onion powder, cayenne, salt, and black pepper in a large shallow dish until evenly blended.
03 - Remove chicken from marinade, allowing excess buttermilk to drip off. Press each piece firmly into seasoned flour mixture, coating completely and ensuring adhesion. Place on wire rack.
04 - Pour oil into large heavy skillet or deep fryer. Heat to 350°F, maintaining consistent temperature throughout frying process.
05 - Working in batches to avoid overcrowding, carefully add chicken to hot oil. Fry 8-12 minutes per side, turning once, until golden brown, crisp, and internal temperature reaches 165°F.
06 - Transfer fried chicken to clean wire rack or paper towels to drain. Let rest 5 minutes before serving to retain juices and ensure crisp coating.